Intravenous heroin injection results in euphoric feelings with a delay of only 10 seconds or less from the time of injection to the onset of the rush. If a user injects heroin into a muscle instead of vein, these effects can take 5 to 10 minutes to onset or 10 to 15 minutes to appear when users smoke or snort the drug. This delay leads many heroin users to opt for intravenous injection. When heroin first hits, users feel a mixture of intense feelings known as a "rush," described as euphoria and intense relaxation. Users also report feelings of intense heat and warmth as the heroin moves from the injection site into the bloodstream. Users commonly reported that the first heroin high ushers users into a dream-like state that is intensely euphoric, so much so that it is nearly impossible to reach again. Euphoric feelings tend to dissipate as tolerance builds and with repeated use, leading many heroin users to up dosages to unsafe levels. Heroin has many noticeable short and long term effects. In addition to the euphoric feelings associated with heroin, the body begins to feel heavy and sleepiness sets in. Many heroin users also experience difficulty breathing. Often heroin users experience a pervasively dry mouth, have difficulty coughing and experience nausea or an upset stomach. Long term heroin users often experience digestive problems that can result in near permanent constipation. Those who inject heroin face a host of additional physical problems including the telltale scarring, abscesses and infections along the inner arms which collectively are known as track marks. Additionally, intravenous users place themselves at significant risk for contracting blood diseases such as HIV and Hepatitis. Heroin is a powerful narcotic and heroin overdose is a highly likely occurrence for both new and long term users. As a central nervous system depressant, heroin slows down both heartbeat and breathing until the user loses consciousness and ultimately starves the body of oxygen. Since death is not instantaneous, proper medical treatment during a heroin overdose can save the life of a user. New users frequently take too much heroin out of inexperience, whereas long term users have developed a tolerance to heroin and need increasing large doses and make using a lethal dose more likely. The purity of heroin can vary greatly, resulting in accidentally ingesting a much larger dose than anticipated. Furthermore, taking heroin in combination with other drugs or alcohol can heighten the negative side effects and make a heroin overdose more likely.

Centre Epiderme

Centre Epiderme is the one-stop for skin care. Moisturizers help keep skin youthful with elasticity. The epidermis is the outer layer of the skin. The epidermis helps the skin to regulate body temperature. The epidermis with the dermis forms the cutis. The epidermis is composed of four to five layers of skin, depending on the region of skin. The epidermis contains no blood vessels and nourishment of cells is by diffusion in the deepest layers from blood capillaries extending to the upper layers of the dermis. The amount and distribution of melanin pigment in the epidermis results in skin color variation in Homo sapiens. Melanin is in the small melanosomes, particles formed in melanocytes from surrounding keratinocytes. The size, number and arrangement of the melansomes varies between racial groups, but while the number of melanocytes can vary between different body regions, the number of melansomes remain the same in individual body regions in all human beings. In white and oriental skin, the melansomes aggregate but are small in size. Comparatively, in black skin, the melansomes are larger and distributed more evenly. The number of melansomes in the keratinocytes increases with UV radiation exposure, while their distribution remains largely unaffected.